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Aedes

Removing the vectors that spread dengue/yellow fever/chikungunya/Zika virus

Organisms: the mosquitoes Ae. aegypti and Ae. albopictus

Laboratories: Akbari (UC Riverside), Alphey (Pirbright Institute), Esvelt (MIT), various (CSIRO)

Safeguards: Always employed: split drive (separated drive components), barrier confinement (multiple doors and air curtains).
Sometimes employed: ecological confinement (not endemic in London, Boston, Melbourne)

Proposal:
Current efforts focus on characterizing components necessary for the construction of RNA-guided gene drives in Aedes mosquitoes. Our collaboration with the Akbari group and CSIRO focuses on building drive systems for alteration and suppression in Aedes albopictus, the Asian tiger mosquito, while the Alphey group is exploring the possibility of building daisy drive system in Aedes aegypti.